Investigating DNA repair mechanisms in hypoxic brain.
IN VIVO DNA REPAIR MECHANISMS AND CARCINOGENESIS. A Dissertation. submitted to the Faculty of the. Graduate School of Arts and Sciences. of Georgetown University. in partial fulfillment of the requirements for the degree of. Doctor of Philosophy. in Tumor Biology. By. Jordan Covington Woodrick, B.S. Washington, DC March 27, 2014.
PhD thesis Rasmus Nielsen Klitgaard, M.Sc. Antibiotic Drug Discovery Potentiation of the quinolones and targeting the initiation of DNA replication This thesis has been submitted to the PhD School of The Faculty of Science, University of Copenhagen, Denmark, 28. February 2018.
PhD and MD theses must not normally exceed 80,000 words (excluding appendices and the bibliography). MPhil theses must not normally exceed 50,000 words (excluding appendices and the bibliography.) For a detailed list of research degree programme word limits please refer to 7.2.3 in the Study Regulations for Reseach Degree Programmes.
The project is focusing on understanding of DNA repair, both in vitro and in vivo, of nucleotide excision repair pathway in bacteria as well as in human cell. Methodology is mostly based on cutting-edge single-molecule technologies including single-molecule FRET and super-resolution microscopy. The project is the collaboration between laboratories in Poznan University.
The machinery for DNA replication, recombination and repair is strikingly similar in archaea and eukaryotes. We use the halophile Haloferax volcanii as a model organism for archaea. Our laboratory has been pivotal in developing genetic tools for H. volcanii and we have used these to study how DNA replication, repair and recombination underpin genome stability in archaea.
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Role of VHL in DNA double-strand break repair and genomic instability in renal cell carcinoma Julie Lynn Metcalf Doctor of Philosophy Laboratory Medicine and Pathobiology University of Toronto 2013 Abstract DNA repair is essential for maintaining genomic stability and defects in this process significantly increase the risk of cancer.